Agents and Actions

, Volume 16, Issue 3–4, pp 144–146 | Cite as

Histamine secretion induced byN-acetyl cysteine

  • K. E. Barrett
  • J. R. Minor
  • D. D. Metcalfe
Mechanisms of Histamine Release

Abstract

The mucolytic drugN-acetyl cysteine has been shown to release histamine from cultured mouse mast cells and from human basophils. At neutral pH the release was moderate and non-cytotoxic. If the acidity of the drug was not neutralized, this histamine release was markedly potentiated, but was then associated with a reduction in the viability of the cells. However, the high level of release could not be reproduced by simply exposing the cells to an acidic medium. The results are discussed in terms of a possible mechanism for the adverse reactions sometimes observed duringN-acetyl cysteine therapy.

Keywords

Cysteine Mast Cell Histamine Adverse Reaction Acidic Medium 

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References

  1. [1]
    E.A. Swinyard andM.A. Pathak, Surface acting drugs. InThe Pharmacological Basis of Therapeutics (Eds.A. Goodman Gilman, L.S. Goodman andA. Gilman). MacMillan, New York 1980.Google Scholar
  2. [2]
    L.F. Prescott, R.N. Illingworth, J.A.J.H. Critchley, M.J. Stewart, R.D. Adam andA.T. Proudfoot,Intravenous N-acetyl cysteine: the treatment of choice for paracetamol poisoning, Br. med. J.ii, 1097–1100 (1979).Google Scholar
  3. [3]
    B.H. Rumack, R.C. Peterson, G.G. Koch andI.A. Amara,Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment, Archs. intern. Med.141, 380–385 (1981).CrossRefGoogle Scholar
  4. [4]
    S.W.-C. Ho andL.J. Beilin,Asthma associated with N-acetylcysteine infusion and paracetamol poisoning: report of two cases, Br. med. J.287, 876–877 (1983).Google Scholar
  5. [5]
    N.G. Walton, T.A.N. Mann andK.M. Shaw,Anaphylactoid reaction to N-acetylcysteine, Lancetii, 1298 (1979).CrossRefGoogle Scholar
  6. [6]
    K.E. Barrett, D.H. Pluznik andD.D. Metcalfe,Histamine release from the cultured mouse mast cell line PT18 in response to immunologic and nonimmunologic stimuli, Agents and Actions14, 488–493 (1984).CrossRefPubMedGoogle Scholar
  7. [7]
    K.E. Barrett, M. Ennis andF.L. Pearce,Mast cells isolated from guinea pig lung: characterization and studies on histamine secretion, Agents and Actions13, 122–126 (1983).PubMedGoogle Scholar
  8. [8]
    G. Atkinson, M. Ennis andF.L. Pearce,The effect of alkaline earth cations on the release of histamine from rat peritoneal mast cells treated with compound 48/80 and peptide 401, Br. J. Pharmac.65, 395–402 (1979).Google Scholar
  9. [9]
    B. Sredni, M.M. Friedman, C.E. Bland andD.D. Metcalfe,Ultrastructural, biochemical and functional characteristics of histamine-containing cells cloned from mouse bone marrow: tentative identification as mucosal mast cells, J. Immun.131, 915–922 (1983).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • K. E. Barrett
    • 1
  • J. R. Minor
    • 2
  • D. D. Metcalfe
    • 1
  1. 1.Allergic Diseases Section, Laboratory of Clinical InvestigationNational Institute of Allergy and Infectious DiseasesBethesdaUSA
  2. 2.Pharmacy Department, Clinical CentreNational Institutes of HealthBethesdaUSA

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