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, Volume 17, Issue 3–4, pp 392–394 | Cite as

Oxidation of suitable drugs by horseradish peroxidase/hydrogen peroxide results in the oxygenation of arachidonic acid to form hydroperoxyeicosatetraenoic acids in a reverse co-oxidation process

  • J. Baumann
  • I. Just
  • G. Wurm
General Inflammation Studies

Keywords

Peroxide Arachidonic Acid Suitable Drug Hydroperoxyeicosatetraenoic Acid 

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References

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    L.J. Marnett, P. Wlodawer andB. Samuelsson,Light emission during the action of prostaglandin synthetase, Biochem. Biophys. Res. Commun.60, 1286–1294 (1974).CrossRefPubMedGoogle Scholar
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    B. Bösterling andJ.R. Trudell,Production of 5- and 15-hydroperoxyeicosatetraenoic acid from arachidonic acid by halothane free radicals generated by UV-irradiation, Anesthesiology60, 209–213 (1984).PubMedGoogle Scholar
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    P.D. Josephy, T.E. Eling andR.P. Mason, Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase. Mol. Pharm.23, 461–466 (1983).Google Scholar
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    I. Knippel, J. Baumann, F. v. Bruchhausen andG. Wurm,Interactions of sulfhydryl agents and soybean lipoxygenase inhibitors, Biochem. Pharmac.30, 1677–1684 (1981).CrossRefGoogle Scholar
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    C.W. Garner,Peroxidation of free and esterified fatty acids by horseradish peroxidase, Lipids19, 863–868 (1984).Google Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • J. Baumann
    • 1
  • I. Just
    • 1
  • G. Wurm
    • 2
  1. 1.Institut für Pharmakologie der Freien Universität BerlinBerlin 33Federal Republic of Germany
  2. 2.Institut für Pharmazie der Freien Universität BerlinBerlin 33Federal Republic of Germany

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