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Dermatosis in magnesium-deficient hairless rats: Effects of steroidal and non-steroidal anti-inflammatory drugs

Agents and Actions volume 17, pages 352–354 (1986)Cite this article

Abstract

Dermatosis in magnesium-deficient hairless rats has been described as a reproducible model of skin inflammation. It was therefore felt of interest to search for the effects of various anti-inflammatory compounds on this model. Results showed that 1) Dexamethasone acetate completely abolished the rash, 2) Indomethacin, a Non-Steroidal Anti-Inflammatory Drug (NSAID), inhibitor of the cyclooxygenase pathway was quite inactive, 3) Benoxaprofen, a NSAID inhibitor of both cyclooxygenase and lipoxygenase pathways only slightly modified the development of the pathology. Activity of steroidal anti-inflammatory drugs on this model may be related to their immunosuppressive effects.

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Affiliations

  1. Sanofi Research, Clin-Midy Research Center, Avenue du Pr. J. Blayac, 34082, Montpellier, France

    A. Barbier, C. Planchenault, C. Vernhet & J. C. Brelière

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  1. A. Barbier
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  2. C. Planchenault
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  3. C. Vernhet
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  4. J. C. Brelière
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Barbier, A., Planchenault, C., Vernhet, C. et al. Dermatosis in magnesium-deficient hairless rats: Effects of steroidal and non-steroidal anti-inflammatory drugs. Agents and Actions 17, 352–354 (1986). https://doi.org/10.1007/BF01982643

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  • DOI: https://doi.org/10.1007/BF01982643

Keywords

  • Acetate
  • Dexamethasone
  • Indomethacin
  • Skin Inflammation
  • Immunosuppressive Effect