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Human peritoneal macrophages: Clinical models of inflammation and potential targets of antiinflammatory drugs

  • Experimental Models of Inflammation
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Abstract

Human peritoneal macrophages have been obtained from patients with renal disease undergoing chronic peritoneal dialysis, patients with ascites and at laparoscopy. These macrophages in general have both morphological and enzymatic characteristics of activated macrophages, as judged by criteria derived from animal experiments. Human peritoneal macrophages produce a variety of eicosanoids, including leukotriene B4 and leukotriene C4. These cells are suitable for studies onin vitro andin vivo effects of drugs, and for investigation of changes in macrophage activity occurring in human diseases.

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Authors and Affiliations

  1. Departments of Internal Medicine and Pharmacology, Erasmus University, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    J. H. P. Wilson & I. L. Bonta

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  1. J. H. P. Wilson
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  2. I. L. Bonta
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Wilson, J.H.P., Bonta, I.L. Human peritoneal macrophages: Clinical models of inflammation and potential targets of antiinflammatory drugs. Agents and Actions 17, 338–341 (1986). https://doi.org/10.1007/BF01982639

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