Agents and Actions

, Volume 17, Issue 3–4, pp 312–313 | Cite as

The effect of glucocorticoids on lyso-PAF formationin vitro andin vivo

  • L. Parente
  • M. F. Fitzgerald
  • R. J. Flower
  • G. De Nucci
Corticosteroid Actions in Infalmmation




  1. [1]
    R. Roubin, M. Tence, J.M. Mencia-Huerta, B. Arnoux, E. Ninio andJ. Benveniste,A Chemicallydefined Monokine: Macrophage-derived Platelet-Activating Factor (PAF-acether), Lymphokines8, 249–276 (1983).Google Scholar
  2. [2]
    D.H. Albert andF. Snyder,Biosynthesis of 1-Alkyl-2-Acetyl-sn-Glycero-3-Phosphocholine (Platelet-Activating Factor) from 1-Alkyl-2-Acyl-sn Glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A 2 and acetyltransferase activities during phagocytosis and ionophore stimulation, J. Biol. Chem.,258, 97–102 (1983).PubMedGoogle Scholar
  3. [3]
    G.J. Blackwell, R. Carnuccio, M. Di Rosa, R.J. Flower, L. Parente andP. Persico,Macrocortin: a Polypeptide Causing the Anti-phospholipase Effect of Glucocorticoids, Nature287, 147–149 (1980).CrossRefPubMedGoogle Scholar
  4. [4]
    M. Di Rosa, R.J. Flower, F. Hirata, L. Parente andF. Russo-Marie,Nomenclature announcement. Antiphospholipase Proteins, Prostaglandins28, 441–442 (1984).CrossRefPubMedGoogle Scholar
  5. [5]
    L. Parente andR.J. Flower,Hydrocortisone and ‘Macrocortin’ Inhibit the Zymosan-induced Release of Lyso-PAF from Rat Peritoneal Leucocytes, Life Sci.36, 1225–1231 (1985).CrossRefPubMedGoogle Scholar
  6. [6]
    P.J. Piper andJ.R. Vane,Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs, Nature223, 29–35 (1969).PubMedGoogle Scholar
  7. [7]
    M.L. Blank, T.C. Lee, V. Fitzgerald andF. Snyder,A Specific Acetylhydrolase for 1-Alkyl-2-Acetyl-sn-Glycero-3-Phosphocholine (a Hypotensive and Plateletactivating Lipid), J. Biol. Chem.256, 175–178 (1981).PubMedGoogle Scholar
  8. [8]
    L. Parente andR.J. Flower, The Generation of Lyso-PAF in Experimental Inflammation. InInflammatory Mediators (EdsG.A. Higgs andT.J. Williams). Macmillan 1985, pp. 65–71.Google Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • L. Parente
    • 1
  • M. F. Fitzgerald
    • 1
  • R. J. Flower
    • 2
  • G. De Nucci
    • 1
  1. 1.Wellcome Research LaboratoiresDept. of Mediator PharmacologyBeckenhamU.K.
  2. 2.Dept. of PharmacologyUniversity of BathBathU.K.

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