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The influence of a new corticosteroid, budesonide, on anaphylactic bronchoconstriction and SRS-A release in the guinea pig

  • Immunosuppression and Inflammation
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Abstract

Groups of guinea pigs sensitized with ovaibumin were treated with budesonide and beclomethasone dipropionate, respectively, in an intraperitoneal dose of 50 mg/kg. 20 h later, the anaphylactic release of histamine and slow reacting substance of anaphylaxis (SRS-A) from chopped lung tissue was studied. Whereas the corticosteroids studied had no effect on the tissue content of histamine or on the amount of antigen-induced release of this autacoid, budesonide and beclomethasone dipropionate to a great extent inhibited the release of SRS-A. The anti-anaphylactic effect of budesonide and beclomethasone was also shown in sensitized guinea pigs pretreated with mepyramine, 2.5 mg/kg intraperitoneally, and challenged with nebulized ovalbumin. We suggest that the partial protection given by the corticosteroids budesonide and beclomethasone dipropionate is due to the inhibition of SRS-A release.

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  1. Research and Development Laboratories, AB Draco, Box 1707, S-221 01, Lund, Sweden

    Kjell Forsberg & Lars Sörenby

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  1. Kjell Forsberg
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  2. Lars Sörenby
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Subsidiary of AB Astra, Sweden.

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Forsberg, K., Sörenby, L. The influence of a new corticosteroid, budesonide, on anaphylactic bronchoconstriction and SRS-A release in the guinea pig. Agents and Actions 11, 391–395 (1981). https://doi.org/10.1007/BF01982476

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  • DOI: https://doi.org/10.1007/BF01982476

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