Archives of Toxicology

, Volume 66, Issue 9, pp 679–680 | Cite as

Potential neurotoxin formation in thermally degraded synthetic ester turbine lubricants

  • P. W. Centers
Letter to the Editors


Under extreme conditions of thermal degradation, a potent neurotoxin, trimethylolpropane phosphate (TMPP), may be formed by reaction of tricresyl phosphate (TCP, an anti-wear additive) and trimethylolpropane esters (TMPE) of carboxylic acids that may be contained in turbine engine lubricant formulations. The neurotoxin is only formed at extreme temperatures (350–700° C), which has minimized concern for use of the synthetic lubricants under intended applications; however, since researchers are often not privy to the proprietary composition of such lubricants, extreme caution should be exercised in studies of or applications of synthetic lubricatns degraded under extreme conditions.

Key words

Turbine lubricant Trimethylolpropane esters Tricresyl phosphate Trimethylolpropane phosphate Neurotoxin 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • P. W. Centers
    • 1
  1. 1.Aero Propulsion and Power DirectorateWright Laboratory, WL/POSLWright-Patterson Air Force BaseUSA

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