, Volume 34, Issue 10, pp 1323–1325 | Cite as

Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon

  • W. Schmidt
  • E. Jähnchen


13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum proteinbinding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.


Albumin Serum Protein Structural Difference Mammalian Species Binding Characteristic 
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Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • W. Schmidt
    • 1
  • E. Jähnchen
    • 1
  1. 1.Department of PharmacologyUniversity of MainzMainz(Federal Republic of Germany)

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