Experientia

, Volume 34, Issue 10, pp 1294–1296 | Cite as

Histamine H1- and H2-receptor-mediated gastric microcirculatory effects in the aetiology of stress ulceration in the rat stomach

  • C. H. Cho
  • C. W. Ogle
Specialia

Summary

Stress produced severe mucosal ulcers, increased mucosal microcirculation and lowered mast cell counts in the glandular wall of rat stomachs. Mepyramine i.m. or metiamide i.p. effectively prevented both ulceration and microcirculatory changes but not stress-reduced mast cell counts.

Keywords

Cell Count Mast Cell Histamine Mast Stress Ulceration 

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Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • C. H. Cho
    • 1
  • C. W. Ogle
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of Hong KongHong Kong(Hong Kong)

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