, Volume 34, Issue 10, pp 1294–1296 | Cite as

Histamine H1- and H2-receptor-mediated gastric microcirculatory effects in the aetiology of stress ulceration in the rat stomach

  • C. H. Cho
  • C. W. Ogle


Stress produced severe mucosal ulcers, increased mucosal microcirculation and lowered mast cell counts in the glandular wall of rat stomachs. Mepyramine i.m. or metiamide i.p. effectively prevented both ulceration and microcirculatory changes but not stress-reduced mast cell counts.


Cell Count Mast Cell Histamine Mast Stress Ulceration 
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  1. 2.
    C.H. Cho and C.W. Ogle, Proc. 12th Singapore-Malaysia Congr. Med., in press.Google Scholar
  2. 3.
    S. Dai, C.W. Ogle and C.H. Lo, Eur. J. Pharmac.33, 277 (1975).CrossRefGoogle Scholar
  3. 4.
    S. Bonfils and A. Lambling, in: Pathophysiology of Peptic Ulcer, p. 162. Ed. S.C. Skoryna. McGill University Press, Montreal 1963.Google Scholar
  4. 5.
    D.A. Brodie, Gastroenterology43, 107 (1962).PubMedGoogle Scholar
  5. 6.
    C.H. Cho and C.W. Ogle, Eur. J. Pharmac.43, 315 (1977).CrossRefGoogle Scholar
  6. 7.
    C.H. Cho and C.W. Ogle, Eur. J. Pharmac.48, 97 (1978).CrossRefGoogle Scholar
  7. 8.
    S. Dai and C.W. Ogle, Eur. J. Pharmac.30, 86 (1975).CrossRefGoogle Scholar
  8. 9.
    P.H. Guth and P. Hall, Gastroenterology50, 562 (1966).PubMedGoogle Scholar
  9. 10.
    T. Räsänen, in: Peptic Ulcer, p. 237. Ed. C.J. Pfeiffer. Munksgaard, Copenhagen 1971.Google Scholar
  10. 11.
    J.C. Schwartz, in: Peptic Ulcer, p. 190. Ed. C.J. Pfeiffer, Munksgaard, Copenhagen 1971.Google Scholar
  11. 12.
    T. Räsänen, Gastroenterology38, 70 (1960).PubMedGoogle Scholar
  12. 13.
    C.W. Ogle and C.H. Cho, Pharmac. Res. Commun.9, 679 (1977).Google Scholar
  13. 14.
    I.H.M. Main and B.J.R. Whittle, J. Physiol., Lond.246, 33P (1975).Google Scholar
  14. 15.
    J.W. Black, W.A.M. Duncan, C.J. Durant, C.R. Ganellin and E.M. Parsons, Nature, Lond.236, 385 (1972).Google Scholar
  15. 16.
    J. Bugajski, J. Hano and L. Danek, Eur. J. Pharmac.36, 237 (1976).CrossRefGoogle Scholar
  16. 17.
    S. Okabe, K. Takeuchi, T. Urushidani and K. Takagi, Am. J. dig. Dis.22, 677 (1977).CrossRefPubMedGoogle Scholar
  17. 18.
    B.M. Johnston and D.A.A. Owen, Eur. J. Pharmac.44, 355 (1977).CrossRefGoogle Scholar
  18. 19.
    S. Dai and C.W. Ogle, Eur. J. Pharmac.26, 15 (1974).CrossRefGoogle Scholar
  19. 20.
    K. Takagi and S. Okabe, Eur. J. Pharmac.10, 378 (1970).CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • C. H. Cho
    • 1
  • C. W. Ogle
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of Hong KongHong Kong(Hong Kong)

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