Agents and Actions

, Volume 32, Issue 3–4, pp 347–350 | Cite as

Effect of PAF on erythrocyte membrane heterogeneity: A fluorescence study

  • A. Kantar
  • P. L. Giorgi
  • G. Curatola
  • R. Fiorini
Inflammation and Immunomodulation

Abstract

The effect of platelet activating factor, PAF, on the erythrocyte membrane heterogeneity was investigated by measuring the steady-state fluorescence anisotropy and fluorescence decay of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated in hemoglobin-free erythrocyte membranes. PAF induced a significant increase of the lipid order in the exterior part of the membrane and a decrease in membrane heterogeneity. These results indicate that PAF may cause changes in the physico-chemical structure of the erythrocyte membrane.

Keywords

Lipid Activate Factor Platelet Activate Erythrocyte Membrane Platelet Activate Factor 

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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • A. Kantar
    • 1
  • P. L. Giorgi
    • 1
  • G. Curatola
    • 2
  • R. Fiorini
    • 2
  1. 1.Department of PediatricsUniversity of AnconaAnconaItaly
  2. 2.Department of BiochemistryUniversity of AnconaAnconaItaly

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