Agents and Actions

, Volume 32, Issue 3–4, pp 182–187 | Cite as

Comparative effects of two potentiating peptides (KPP and BPP9a) on kinin-induced rat paw edema

  • P. D. Fernandes
  • J. A. Guimarães
  • J. Assreuy
Allergy, Histamine and Kinins

Abstract

We have previously shown that KPP, a kinin potentiating peptide generated by tryptic digestion of human plasma proteins potentiated kinin effects on isolated smooth muscle preparations like guinea-pig ileum with high potency and specificity. We also obtained evidence suggesting that, unlike other potentiating peptides, KPP exerts its effect by a mechanism different from the inhibition of kinin metabolism by angiotensin converting enzyme, neutral endopeptidase and kininase I. Here we show the potentiating effect of KPP and of BPP9a, a potentiator derived from snake venom, towards the rat paw edema induced by bradykinin (BK). Our results show that: a) KPP is 25-fold more active than BPP9a in potentiating rat paw edema elicited by BK; b) like BPP9a, KPP is specific in potentiating kinin-induced edema, being ineffective in potentiating edema induced by histamine or serotonin; and c) DesArg9-BK (DABK) elicits a small edematogenic response which can be potentiated by both KPP and BPP9a.

Keywords

Peptide Serotonin Angiotensin Histamine Angiotensin Converting Enzyme 

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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • P. D. Fernandes
    • 1
  • J. A. Guimarães
    • 1
  • J. Assreuy
    • 1
  1. 1.Departamento de Farmacologia Básica e Clínica, Instituto de Ciências Biomédicas/Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrasil

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