Skip to main content
SpringerLink
Log in

In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage

  • Allergy, Histamine and Kinins
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

We investigated the influences of ketoprofen on the proteoglycan (PG) turnover of human articular cartilage explants in three groups: normal young with a high basal PG synthesis, normal adult and osteoarthritis cartilage, both with a low basal PG synthesis. Ketoprofen had no influence on the mean PG synthesis rate of normal adult and OA cartilage after 4 days of culture nor on the cartilage PG content after 8 days of culture. There was no relation between the histological grade of OA and effects of ketoprofen. In normal young cartilage ketoprofen induced an increase of the PG synthesis rate when added to the culture in a concentration of 10−4 M. No correlation existed between the effect of ketoprofen and the basal PG synthesis of normal cartilage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. J. De Vries, W. B. Van Den Berg, E. Vitters and L. B. A. Van De Putte,The influence of antirheumatic drugs on basal and accelerated breakdown of articular proteoglycans. Agents and Actions23, 52–54 (1988).

    PubMed  Google Scholar 

  2. M. J. Palmoski and K. D. Brandt,In vivo effect of aspirin on canine osteoarthritic cartilage. Arthritis Rheum.26, 994–1001 (1983).

    PubMed  Google Scholar 

  3. L. S. McKenzie, B. A. Horsburgh, P. Ghosh and T. K. F. Taylor,Effect of antiinflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage. Ann. Rheum. Dis.35, 487–497 (1976).

    PubMed  Google Scholar 

  4. M. J. Palmoski and K. D. Brandt,Effects of some nonsteroidal antiinflammatory drugs on proteoglycan metabolism and organization in canine articular cartilage. Arthritis Rheum.23, 1010–1020 (1980).

    PubMed  Google Scholar 

  5. M. W. Whitehouse and H. Boström,The effect of some antiinflammatory (antirheumatic) drugs on the metabolism of connective tissues. Biochem. Pharmacol.11, 1175–1201 (1962).

    Article  PubMed  Google Scholar 

  6. K. D. Brandt and M. J. Palmoski,Effects of salicylates and other nonsteroidal antiinflammatory drugs on articular cartilage. Am. J. Med.77(1A), 65–69 (1984).

    Google Scholar 

  7. P. Ghosh,Antirheumatic drugs and cartilage. Clin. Rheumatol.2, 309–338 (1988).

    Google Scholar 

  8. B. J. De Vries, W. B. Van Den Berg and L. B. A. Van De Putte,In vivo and in vitro effects of tiaprofenic acid on glycosaminoglycan synthesis by intact murine articular cartilage. InTiaprofenic Acid. International Congress of Rheumatology. Excerpta Medica (Ed. O.G. Nilsen) pp. 69–74, Amsterdam 1985.

    Google Scholar 

  9. O. Huber-Bruning, B. Wilbrink, J. E. Vernooy, J. W. J. Bijlsma, W. Den Otter and J. Huber,Contrasting in vitro effects of retionol and mononuclear cell factor on young and old human cartilage. J. Pathol.150, 21–27 (1986).

    Article  PubMed  Google Scholar 

  10. J. Erlendsson, L. Ejstrup, N. Peters, Daugaard, A. Le Liboux, G. Jakobsen,Ketoprofen in plasma and synovial fluid. Ketoprofen summit conference, International Congress of Rheumatology, Sydney 1985.

  11. W. S. Mitchell, P. Scott, A. C. Kennedy, P. M. Brooks, R. Templeton and M. G. Jeffries,Clinico-pharmacological studies on ketoprofen (‘Orudis’). Curr. Med. Res. Opin.3, 423–430 (1975).

    Google Scholar 

  12. A. A. Dogterom, O. Huber-Bruning, J. E. Vernooy, B. Wilbrink, W. Den Otter, J. Huber,Matrix depletion of young and old human articular cartilage by cultured autologous synovium fragments: a chondrocyte independent effect. Rheumatol. Int.5, 169–173 (1985).

    Article  PubMed  Google Scholar 

  13. P. Whiteman,The quantitative measurement of alcian blue glycosamino-glycan complexes. Biochem. J.131, 343–350 (1973).

    PubMed  Google Scholar 

  14. G. P. J. Van Kampen, J. P. Veldhuijzen,Aggregated chondrocytes as a model system to study cartilage metabolism. Exp. Cell. Res.140, 440–443, (1982).

    Article  PubMed  Google Scholar 

  15. H. J. Mankin, H. Dorfman, L. Lipiello and A. Zarius,Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. J. Bone Joint Surg.53A, 523–537 (1971).

    Google Scholar 

  16. M. J. Palmoski and K. D. Brandt,Proteoglycan depletion, rather than fibrillation, determines the effects of salicylate and indomethacin on osteoarthritic cartilage. Arthritis Rheum.28, 548–553 (1985).

    PubMed  Google Scholar 

  17. D. A. Kalbhen,The influence of NSAIDs on morphology of articular cartilage. Scan. J. Rheumatol.77(suppl), 13–22 (1989).

    Google Scholar 

  18. S. Collier and P. Ghosh,Evaluation of the effects of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedure. Ann. Rheum. Dis.48, 372–381 (1989).

    PubMed  Google Scholar 

  19. K. D. Brandt and S. Slowman-Kovacs,Nonsteroidal antiinflammatory drugs in treatment of osteoarthritis. Clin. Orthop.213, 86–91 (1986).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Rheumatology, University Hospital Utrecht, HP: F. 02.223, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands

    B. Wilbrink, M. J. Van der Veen, J. L. A. M. Van Roy & O. Huber-Bruning

  2. Department of Pathology, University Hospital Utrecht, The Netherlands

    J. Huber

Authors
  1. B. Wilbrink
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. J. Van der Veen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Huber
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. L. A. M. Van Roy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. Huber-Bruning
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Part of the results were presented during the XVIIth ILAR Congress of Rheumatology, 1989. Abstract in: Scan. J. Rheum., 1989; Suppl. 83: 29–32.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wilbrink, B., Van der Veen, M.J., Huber, J. et al. In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage. Agents and Actions 32, 154–159 (1991). https://doi.org/10.1007/BF01980867

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01980867

Keywords

Search

Navigation