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European Child & Adolescent Psychiatry

, Volume 4, Issue 4, pp 280–283 | Cite as

Development of mania in close association with tricyclic antidepressant administration in Children. A report of two cases

  • J. J. D. Briscoe
  • R. C. Harrington
  • M. Prendergast
Article

Abstract

Two depressed children with a strong family history of affective disorder developed manic episodes shortly after starting treatment with low dose antidepressant therapy. In one of these cases manic symptoms appeared on each of the three occasions that tricyclic medication was started or increased in dosage. There are few reports of manic switching in young people and none that describe such a close temporal association between the administration of antidepressants and the development of mania. Children with a family history of affective disorder may be more susceptible to manic switching.

Keywords

Mania Switching Adolescent Depression Tricyclic 

Résumé

Deux enfants déprimés, au passé familial marqué par un fort trouble affectif, ont développé des manies peu après avoir commencé un traitement à base d'antidépesseurs à faible dose. Dans l'un de ces cas, des symptomes maniaques sont apparus toutes les trois fois que la médication tricyclique fut commencé ou lors de l'augmentation de la dose des antidépresseurs. Il existe bien quelques rapports sur l'apparition de tels troubles chez les jeunes gens, mais aucun ne décrit un tel lien chronologique de cause à effet entre l'administration d'antidépresseurs et de développement de manies. Les enfants ayant un passé familial affectivement difficile s'avèrent être plus propices à l'apparition d'un tel trouble.

Zusammenfassung

Zwei depressive Kinder mit einer stark vorbelasteten Familienanamnese für affektive Störungen entwickelten manische Episoden kurz nach Beginn einer Behandlung mit einem niedrig dosierten Antidepressivum. Bei einem der beiden Fälle traten die manischen Symptome bei allen drei Gelegenheiten auf, zu denen entweder mit einer trizyklischen Medikation begonnen oder deren Dosierung erhöht wurde. Es gibt nur wenige Berichte über einen Wechsel hin zur Manie bei jungen Menschen, und in keinem derartigen Fall ist bislang so ein enger zeitlicher Zusammenhang zwischen der Gabe von Antidepressiva und der Entwicklung einer Manie beschrieben worden. Kinder mit einer positiven Familienanamnese für affektive Störungen könnten für einen Wechsel zur Manie empfänglicher sein.

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Copyright information

© Hogrefe & Huber Publishers 1995

Authors and Affiliations

  • J. J. D. Briscoe
    • 1
  • R. C. Harrington
    • 2
  • M. Prendergast
    • 3
  1. 1.Department of PsychiatryUniversity of Birmingham, All Saints HospitalBirmingham
  2. 2.Dept of Psychiatry, Child and Adolescent PsychiatryRoyal Manchester Children's HospitalPendlebury
  3. 3.The Children's HospitalBirmingham

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