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Pharmaceutisch Weekblad

, Volume 14, Issue 2, pp 46–49 | Cite as

Liquid chromatographic estimation of tranylcypromine in human plasma

  • P. G. L. C. Krugers Dagneaux
  • C. P. G. G. Loohuis
  • J. T. Klein Elhorst
  • T. S. Van der Veer
Articles

Abstract

A simple, selective and quantitative estimation of tranylcypromine using liquid chromatography and electrochemical detection with apomorphine as internal standard in human plasma is described. Sample preparation is done by liquid-liquid extraction. The absolute mean recovery of apomorphine is 95%, the recovery of tranylcypromine is 81%. This method gives a simple estimation method to assay plasma concentrations of tranylcypromine in the therapeutic range (5–200 ng/ml) with good reproducibility and linearity.

Keywords

Chromatography, high pressure liquid Detection, electrochemical Plasma Tranylcypromine 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • P. G. L. C. Krugers Dagneaux
    • 1
  • C. P. G. G. Loohuis
    • 2
  • J. T. Klein Elhorst
    • 2
  • T. S. Van der Veer
    • 2
  1. 1.Department of Clinical PharmacyMedisch Spectrum TwenteKA Enschedethe Netherlands
  2. 2.Department of PsychiatryMedisch Spectrum Twentethe Netherlands

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