Liquid chromatographic estimation of tranylcypromine in human plasma
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A simple, selective and quantitative estimation of tranylcypromine using liquid chromatography and electrochemical detection with apomorphine as internal standard in human plasma is described. Sample preparation is done by liquid-liquid extraction. The absolute mean recovery of apomorphine is 95%, the recovery of tranylcypromine is 81%. This method gives a simple estimation method to assay plasma concentrations of tranylcypromine in the therapeutic range (5–200 ng/ml) with good reproducibility and linearity.
KeywordsChromatography, high pressure liquid Detection, electrochemical Plasma Tranylcypromine
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