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Quantitative determination of particulate contamination in intravenous administration sets

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Abstract

Particle counts were performed on 1,000 intravenous administration sets from ten suppliers on the Swiss market using a HIAC/Royco electronic counter. The following main conclusions may be drawn from the results of this study:

  • the small particles were the most numerous, regardless of the type of set;

  • the differences in the counts obtained for the different suppliers' sets tended to level off for particles larger than 10μm;

  • the drip chamber and latex connector may be two important sources of particles;

  • the particulate contamination from the sets is relatively low compared with the amount of particles contained in the parenteral solutions.

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Authors and Affiliations

  1. Service of Pharmacy, Centre Hospitalier Universitaire Vaudois (C.H.U.V.), CH-1011, Lausanne, Switzerland

    E. R. Di Paolo,  B. Hirschi &  A. Pannatier

Authors
  1. E. R. Di Paolo
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  2. B. Hirschi
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  3. A. Pannatier
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Di Paolo, E.R., Hirschi, B. & Pannatier, A. Quantitative determination of particulate contamination in intravenous administration sets. Pharmaceutisch Weekblad Scientific Edition 12, 190–195 (1990). https://doi.org/10.1007/BF01980045

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  • DOI: https://doi.org/10.1007/BF01980045

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