Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin

  • K. Riesbeck
  • A. Forsgren
Notes

Abstract

A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 µg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 µg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.

Keywords

Internal Medicine Tumour Necrosis Tumour Necrosis Factor Colony Stimulate Factor Stimulate Factor 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1990

Authors and Affiliations

  • K. Riesbeck
    • 1
  • A. Forsgren
    • 1
  1. 1.Department of Medical MicrobiologyUniversity of Lund, Malmö General HospitalMalmöSweden

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