Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin
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A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 µg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 µg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.
KeywordsInternal Medicine Tumour Necrosis Tumour Necrosis Factor Colony Stimulate Factor Stimulate Factor
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- 13.Pusztai-Markos S, Hauss K In vitro effect of different antimicrobial agents on IL-2 production and IL-2 receptor expression of human lymphocytes. In: Gillissen G, Opferkuch W, Peters G, Pulverer G (ed): The influence of antibiotics on the host-parasite relationship. Springer Verlag, Berlin, 1989.Google Scholar
- 14.Riesbeck K, Andersson J, Gullberg M, Forsgren A Fluorinated 4-quinolones induce hyperproduction of interleukin-2. Proceedings of the National Academy Sciences of the USA 1989, 86: 2809–2813.Google Scholar
- 17.O'Garra A Peptide regulatory factors: interleukins and the immune system (1). Lancet 1989, i: 943–947.Google Scholar
- 18.Ibrahim MS, Maged ZA, Haron A, Khalil RY, Attallah AM Antibiotics and immunity: effects of antibiotics on mitogen responsiveness of lymphocytes and interleukin-2 production. Chemiotherapia 1988, 7: 369–372.Google Scholar