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Effect of SAS 650—Furofenac®) on malondialydehyde production by platelets

Agents and Actions volume 14, pages 735–737 (1984)Cite this article

Abstract

The activity of SAS 650, a new anti-inflammatory drug, onex vivo andin vitro MDA production by platelets was compared to that of aspirin. The drug induced dose-dependent inhibition ofin vitro MDA production by rat and guinea-pig platelets and also had good activity after 30 second of incubation in rat platelets, quicker than aspirin.

SAS 650 preincubation reduced thein vitro inhibitory effect of ASA, as shown also byex vivo experiments.

The results of the present study support the involvement of SAS 650 in the platelet cyclooxygenase pathway.

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Affiliations

  1. Alfa Ricerche S.p.a., Via Ragazzi del '99 n. 5, 40133, Bologna, Italy

    G. P. Corbelli, L. Stanzani, R. Mastacchi, M. Barbanti & L. Montecchi

Authors
  1. G. P. Corbelli
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  2. L. Stanzani
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  3. R. Mastacchi
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  4. M. Barbanti
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  5. L. Montecchi
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Corbelli, G.P., Stanzani, L., Mastacchi, R. et al. Effect of SAS 650—Furofenac®) on malondialydehyde production by platelets. Agents and Actions 14, 735–737 (1984). https://doi.org/10.1007/BF01978917

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  • DOI: https://doi.org/10.1007/BF01978917

Keywords

  • Aspirin
  • Good Activity
  • Onex
  • Cyclooxygenase Pathway
  • Platelet Cyclooxygenase