Agents and Actions

, Volume 14, Issue 5–6, pp 723–728 | Cite as

Quantitation of arthritis by99mTc-uptake measurements in the mouse knee-joint: correlation with histological joint inflammation scores

  • Jan Willem Lens
  • Wim B. van den Berg
  • Levinus B. A. van de Putte
Immunosuppression and Inflammation


A method is described to detect and to quantitate inflammation in knee-joints of mice. Approximately 10 μCi99mTechnetium pertechnetate (99mTc) is injected subcutaneously in the neck region and the accumulation of the short-lived isotope in the knee-joint is detected by external gamma counting.99mTc-uptake values correlate well with histological grading of joint inflammation at various intervals after induction of the inflammation. The method can be used to detect changes in activity of unilateral as well as bilateral joint inflammation using either the ratio of99mTc uptake in the right knee versus that in the left knee or absolute99mTc-uptake values.


Arthritis Histological Grade Neck Region Joint Inflammation Left Knee 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • Jan Willem Lens
    • 1
  • Wim B. van den Berg
    • 1
  • Levinus B. A. van de Putte
    • 1
  1. 1.Department of Rheumatology, St Radboud HospitalUniversity of NijmegenThe Netherlands

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