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Effect of gold salts,d-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats

Agents and Actions volume 14, pages 707–714 (1984)Cite this article

Abstract

We investigated the therapeutic effect of two gold salts, gold sodium thiomalate (GST, i.m.) and auranofin (p.o.),d-penicillamine (p.o._ and benoxaprofen (p.o.) in rat collagen-induced arthritis using type II collagen from fetal bovine articular cartilage.

GST, but not auranofin, reduced hind paw edema and bone pathology. However, auranofin reduced serum copper and zymosan-induced prostaglandin production from peritoneal macrophages. In contrast, GST increased both serum copper and macrophage prostaglandin production by zymosan.

Benoxaprofen reduced both hind paw edema and pathology, whereasd-penicillamine was without effect. None of these treatments influenced the circulating level of antibody to type II collagen.

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Author notes

  1. Frank DeLustro

    Present address: Medical University of South Carolina, 29425, Charleston, S.C., USA

Affiliations

  1. Wyeth Laboratories, Inc., P.O. Box 8299, 19101, Philadelphia, Pa., USA

    Alan J. Lewis, Richard P. Carlson, Joseph Chang & Frank DeLustro

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  1. Alan J. Lewis
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  2. Richard P. Carlson
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  3. Joseph Chang
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  4. Frank DeLustro
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Lewis, A.J., Carlson, R.P., Chang, J. et al. Effect of gold salts,d-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats. Agents and Actions 14, 707–714 (1984). https://doi.org/10.1007/BF01978912

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  • DOI: https://doi.org/10.1007/BF01978912

Keywords

  • Gold
  • Prostaglandin
  • Therapeutic Effect
  • Articular Cartilage
  • Peritoneal Macrophage