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, Volume 11, Issue 6–7, pp 736–740 | Cite as

Drug metabolism in rats with arthritis induced by 6-sulfanilamidoindazole (6-SAI)

  • D. Müller
  • R. Hirschelmann
Immunosuppression and Inflammation

Abstract

Hexobarbital sleeping time was prolonged and ethylmorphine N-demethylation was inhibited after a single dosage or seven administrations of 6-SAI to old rats. These effects were independent of the development of arthritis. Changes in cytochrome P-450 concentration after 6-SAI treatment were insignificant and thus not responsible for the decrease in drug metabolism.In vitro 6-SAI inhibited ethylmorphine N-demethylation; the inhibition was of a mixed type. 6-SAI bound to cytochrome P-450 and induced a type II spectrum. The magnitude of hexobarbital-induced type I spectral changes was diminished by 6-SAI.

It is concluded that 6-SAI inhibits cytochrome P-450-dependent drug metabolism by binding to cytochrome P-450.

Keywords

Arthritis Single Dosage Drug Metabolism Mixed Type Spectral Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • D. Müller
    • 1
  • R. Hirschelmann
    • 2
  1. 1.Institute of Pharmacology and ToxicologyFriedrich Schiller University JenaJena
  2. 2.Department of Pharmacology, Pharmacy SectionMartin Luther University Halle-WittenbergHalleGerman Democratic Republic

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