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Agents and Actions

, Volume 11, Issue 6–7, pp 602–604 | Cite as

Effect of inflammatory arthritis on dexamethasone receptors in phagocytes—a possible role for plasma factors

  • Isobel P. Braidman
  • K. Livingston
  • I. W. Tomlinson
  • M. I. V. Jayson
  • M. K. Jasani
Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981 Inflammation Revisited: Cellular Aspects
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Abstract

Synovial tissue cells from patients with seropositive rheumatoid arthritis bind dexamethasone in a similar fashion to the classical steroid receptors on other cells. In contrast, synovial fluid cells and blood PMNLs from these patients bind dexamethasone with much reduced affinity. Some component of plasma may interfere with the binding of dexamethasone to its receptor.

Keywords

Rheumatoid Arthritis Arthritis Steroid Dexamethasone Synovial Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    G. Scatchard, Ann. N.Y. Acad. Sci.57, 660–672 (1949).Google Scholar

Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • Isobel P. Braidman
    • 1
  • K. Livingston
    • 2
  • I. W. Tomlinson
    • 2
  • M. I. V. Jayson
    • 2
  • M. K. Jasani
    • 3
  1. 1.Department of MedicineHope HospitalSalfordUK
  2. 2.Department of RheumatologyHope HospitalSalfordUK
  3. 3.Department of Ciba Geigy Research CentreHorshamUK

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