Agents and Actions

, Volume 11, Issue 6–7, pp 536–537 | Cite as

The importance of the production of phosphatidic acid for the release of arachidonic acid in stimulated platelets

  • Eduardo G. Lapetina
  • M. Motasim Billah
Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981 Phospholipase: Role in Cellular Activation


Phosphatidic acid is formed by platelets as a result of the combined activities of phospholipase C and diacylglycerol kinase. The initial thrombin-activated phospholipase C-mediated reaction is quinacrine insensitive and is followed by quinacrine-sensitive phospholipase A2 activities. The phosphatidic acid released probably results in cellular calcium gating, which among other actions, might release arachidonic acid by activating phospholipases A2: Indeed, we have detected a phosphatidic acid-specific phospholipase A2 in platelets, which might have an important role in the liberation of arachidonic acid.


Calcium Arachidonic Acid Combine Activity Phosphatidic Acid Quinacrine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. [1]
    E.G. Lapetina andP. Cuatrecasas, Biochim. Biophys. Acta573, 394–402 (1979).PubMedGoogle Scholar
  2. [2]
    M.J. Broekman, M.W. Ward andA.J. Marcus, J. Clin. Invest.66, 275–283 (1980).PubMedGoogle Scholar
  3. [3]
    R. Walenga, J.Y. Vanderhoek andM.B. Feinstein, J. Biol. Chem.255, 6024–6027 (1980).PubMedGoogle Scholar
  4. [4]
    E.G. Lapetina, M.M. Billah andP. Cuatrecasas, J. Biol. Chem.256, 5037–5040 (1981).PubMedGoogle Scholar
  5. [5]
    E.G. Lapetina, M.M. Billah andP. Cuatrecasas, Nature, New Biology292, 367–369 (1981).Google Scholar
  6. [6]
    R.L. Bell, D.A. Kennerly, N. Stanford andP.W. Majerus, Proc. Natn. Acad. Sci. USA76, 3238–3241 (1979).Google Scholar
  7. [7]
    M.M. Billah, E.G. Lapetina andP. Cuatrecasas, J. Biol. Chem.256, 5399–5403 (1981).PubMedGoogle Scholar
  8. [8]
    M.M. Billah, E.G. Lapetina andP. Cuatrecasas, J. Biol. Chem.255, 10227–10231 (1980).PubMedGoogle Scholar
  9. [9]
    R.F. Irvine andR.M.C. Dawson, Biochem. Biophys. Res. Comm.91, 1399–1405 (1979).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • Eduardo G. Lapetina
    • 1
  • M. Motasim Billah
    • 1
  1. 1.Department of Molecular BiologyThe Wellcome Research LaboratoriesResearch Triangle ParkUSA

Personalised recommendations