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, Volume 11, Issue 6–7, pp 536–537 | Cite as

The importance of the production of phosphatidic acid for the release of arachidonic acid in stimulated platelets

  • Eduardo G. Lapetina
  • M. Motasim Billah
Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981 Phospholipase: Role in Cellular Activation


Phosphatidic acid is formed by platelets as a result of the combined activities of phospholipase C and diacylglycerol kinase. The initial thrombin-activated phospholipase C-mediated reaction is quinacrine insensitive and is followed by quinacrine-sensitive phospholipase A2 activities. The phosphatidic acid released probably results in cellular calcium gating, which among other actions, might release arachidonic acid by activating phospholipases A2: Indeed, we have detected a phosphatidic acid-specific phospholipase A2 in platelets, which might have an important role in the liberation of arachidonic acid.


Calcium Arachidonic Acid Combine Activity Phosphatidic Acid Quinacrine 


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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • Eduardo G. Lapetina
    • 1
  • M. Motasim Billah
    • 1
  1. 1.Department of Molecular BiologyThe Wellcome Research LaboratoriesResearch Triangle ParkUSA

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