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Radioprotective action of haematoporphyrin on X-irradiated trypsin

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Summary

Dose-response curves were obtained for trypsin X-irradiated in aqueous solution (4.6×10−6M), alone or after incubation with haematoporphyrin (Hp). When trypsin was irradiated alone (exposure doses ranging from 10 to 25 kR) the exponential dose-response curve showed a D37 equal to 17200 R. When trypsin was incubated with Hp before irradiation a D37 equal to 61900 R was obtained, with a dose reduction factor of 3.6. Therefore in our experimental conditions Hp shows a highly significant radioprotective action.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Genova, 6, viale Benedetto XV, I-16132, Genova, Italy

    V. Pistoia & Carmela Murolo

  2. Department of Radiology, University of Genova, Genova, Italy

    V. Pistoia & Carmela Murolo

Authors
  1. V. Pistoia
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  2. Carmela Murolo
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Additional information

Acknowledgments. The authors wish to acknowledge the invaluable suggestions and discussion offered by Prof. G. Cittadini.

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Pistoia, V., Murolo, C. Radioprotective action of haematoporphyrin on X-irradiated trypsin. Experientia 36, 873–874 (1980). https://doi.org/10.1007/BF01978623

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