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Neuromuscular blocking activity of dibekacin, a new semisynthetic aminoglycoside antibiotic

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Summary

Dibekacin possesses the untoward effect of producing a neuromuscular blockade. Neostigmine is unable to reverse the neuromuscular blockade produced by dibekacin. Calcium has not only the ability to restore the neuromuscular transmission but also to exert protective action against the neuromuscular blocking activity of dibekacin.

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Authors and Affiliations

  1. Department of Experimental Pharmacology, Medical Faculty, Aristotelian University of Thessaloniki, Thessaloniki, Greece

    A. G. Paradelis, J. S. Tsouras, P. Latsoudes, T. Demetriou & C. Triantaphyllidis

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  1. A. G. Paradelis
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  2. J. S. Tsouras
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  3. P. Latsoudes
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  4. T. Demetriou
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  5. C. Triantaphyllidis
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Paradelis, A.G., Tsouras, J.S., Latsoudes, P. et al. Neuromuscular blocking activity of dibekacin, a new semisynthetic aminoglycoside antibiotic. Experientia 36, 867–868 (1980). https://doi.org/10.1007/BF01978619

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  • DOI: https://doi.org/10.1007/BF01978619

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