Experientia

, Volume 36, Issue 7, pp 854–856 | Cite as

Hypothermia induced in mice by enzyme-mediated depletion of serotonin

  • J. Roberts
  • H. J. Rosenfeld
Article

Summary

Injection of a purified serotonin (and tryptophan)-degrading enzyme into mice produced a pronounced hypothermia when the mice were maintained at 22°C, but not at 30°C. Brain levels of serotonin and tryptophan were strikingly depleted, but concentrations of norepinephrine and dopamine remained unchanged.

Keywords

Enzyme Dopamine Serotonin Norepinephrine Tryptophan 

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • J. Roberts
    • 1
  • H. J. Rosenfeld
    • 1
  1. 1.Sloan-Kettering Institute for Cancer ResearchRyeUSA

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