Hypothermia induced in mice by enzyme-mediated depletion of serotonin
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Injection of a purified serotonin (and tryptophan)-degrading enzyme into mice produced a pronounced hypothermia when the mice were maintained at 22°C, but not at 30°C. Brain levels of serotonin and tryptophan were strikingly depleted, but concentrations of norepinephrine and dopamine remained unchanged.
KeywordsEnzyme Dopamine Serotonin Norepinephrine Tryptophan
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