, Volume 36, Issue 7, pp 854–856 | Cite as

Hypothermia induced in mice by enzyme-mediated depletion of serotonin

  • J. Roberts
  • H. J. Rosenfeld


Injection of a purified serotonin (and tryptophan)-degrading enzyme into mice produced a pronounced hypothermia when the mice were maintained at 22°C, but not at 30°C. Brain levels of serotonin and tryptophan were strikingly depleted, but concentrations of norepinephrine and dopamine remained unchanged.


Enzyme Dopamine Serotonin Norepinephrine Tryptophan 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 2.
    B. Cox and P. Lomax, A. Rev. Pharmac. Tox.17, 341 (1977).CrossRefGoogle Scholar
  2. 3.
    A. Biegon, M. Segal and D. Samuel, Psychopharmacology61, 77 (1979).CrossRefPubMedGoogle Scholar
  3. 4.
    J. Roberts and H.J. Rosenfeld, J. biol. Chem.252, 2640 (1977).PubMedGoogle Scholar
  4. 5.
    J.E. Smith, J.D. Lane, P.A. Shea, W.J. McBride and M.H. Aprison, Analyt. Biochem.64, 149 (1975).CrossRefPubMedGoogle Scholar
  5. 6.
    J.M. Saavedra, M. Brownstein and J. Axelrod, J. Pharmac. exp. Ther.186, 508 (1973).Google Scholar
  6. 7.
    D.L. Bloxam and W.H. Warren, Analyt. Biochem.60, 621 (1974).CrossRefPubMedGoogle Scholar
  7. 8.
    I. Barofsky and A. Feldstein, Experientia26, 990 (1970).PubMedGoogle Scholar
  8. 9.
    W. Feldberg and R.D. Myers, J. Physiol.173, 226 (1964).PubMedGoogle Scholar
  9. 10.
    W. Feldberg, R.F. Hellon and V.J. Lotti, J. Physiol.191, 501 (1967).PubMedGoogle Scholar
  10. 11.
    E. Preston and E. Schönbaum, in: Brain Dysfunction in Infantile Febrile Convulsions p. 75. Ed. M.A.B. Brazier and F. Coceani. Raven, New York 1976.Google Scholar
  11. 12.
    J.J. Jacob and J.-M.T. Girault, in: Body Temperature, p. 183. Ed. P. Lomax and E. Schönbaum. M. Dekker, Inc., New York 1979.Google Scholar
  12. 13.
    A. Pyörnilä and R. Hissa, Experientia35, 59 (1979).CrossRefPubMedGoogle Scholar
  13. 14.
    S.D. Wainwright, Can. J. Biochem.55, 415 (1977).PubMedGoogle Scholar
  14. 15.
    R.P. Francesconi and M. Mager, Am. J. Physiol.227, 402 (1974).PubMedGoogle Scholar
  15. 16.
    J. Bligh and W.H. Cottle, Experientia25, 608 (1969).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • J. Roberts
    • 1
  • H. J. Rosenfeld
    • 1
  1. 1.Sloan-Kettering Institute for Cancer ResearchRyeUSA

Personalised recommendations