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The response of cyclic 3′,5′-AMP and cyclic 3′,5′-GMP phosphodiesterases to experimental diabetes

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Summary

Alloxan diabetes caused a decrease in cyclic AMP phosphodiesterase in all affected rat tissues. Cyclic GMP phosphodiesterase activity was, however, decreased in adipose and liver, but increased in heart and uterus.

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References

  1. G. Senft, G. Schultz, K. Muske and M. Hoffmann, Diabetologia4, 322 (1968).

    Article  CAS  PubMed  Google Scholar 

  2. E. G. Loten and J. G. T. Sneyd, Biochem. J.120, 187 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. P. D. R. House, P. Paulis and H. J. Weideman, Eur. J. Biochem.24, 429 (1972).

    Article  CAS  PubMed  Google Scholar 

  4. B. Zinman and C. H. Hollenberg, J. biol. Chem.249, 2182 (1974).

    Article  CAS  PubMed  Google Scholar 

  5. T. Kono, F. W. Robison and J. A. Sarver, J. biol. Chem.250, 7826 (1975).

    Article  CAS  PubMed  Google Scholar 

  6. V. Manganiello and M. Vaughan, J. biol. Chem.248, 7164 (1973).

    Article  CAS  PubMed  Google Scholar 

  7. J. A. Beavo, J. G. Hardman and E. W. Sutherland, J. biol. Chem.246, 3841 (1971).

    Article  CAS  PubMed  Google Scholar 

  8. W. G. Thompson and M. M. Appleman, Biochemistry10, 311 (1971).

    Article  CAS  PubMed  Google Scholar 

  9. T. R. Russell and I. H. Pastan, J. biol. Chem.249, 7764 (1974).

    Article  CAS  PubMed  Google Scholar 

  10. J. Londesborough, Analyt. Biochem.71, 623 (1976).

    Article  CAS  PubMed  Google Scholar 

  11. O. H. Lowry, N. J. Rosebrough, A. L., Farr and R. J. Randall, J. biol. Chem.193, 265 (1951).

    Article  CAS  PubMed  Google Scholar 

  12. E. G. Loten, F. Assimacopoulos-Jeannet, J. H. Exton and C. R. Park, J. biol. Chem.253, 746 (1978).

    Article  CAS  PubMed  Google Scholar 

  13. C. Correze, R. Auclair and J. Nunez, Molec. cell. Endocr.5, 67 (1976).

    Article  CAS  PubMed  Google Scholar 

  14. I. Das and E. B. Chain, Biochem. J.128, 95P (1972).

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Authors and Affiliations

  1. Departments of Pharmacology and Biochemistry, Howard University, College of Medicine, 20059, Washington D.C., USA

    B. Perez de Gracia, A. R. Rhoads & W. L. West

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  1. B. Perez de Gracia
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  2. A. R. Rhoads
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  3. W. L. West
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Additional information

This research was supported by U.S. Public Health Service grant RO1-AM19364-O1 and MARC training grant No. 1-TO2-GMO50000.

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Perez de Gracia, B., Rhoads, A.R. & West, W.L. The response of cyclic 3′,5′-AMP and cyclic 3′,5′-GMP phosphodiesterases to experimental diabetes. Experientia 36, 824–825 (1980). https://doi.org/10.1007/BF01978592

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  • DOI: https://doi.org/10.1007/BF01978592

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