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, Volume 1, Issue 2, pp 46–48 | Cite as

Are biogenic amines involved in the mechanism of action of the tetrahydrocannabinols?

  • Rose Dagirmanjian
  • Harold C. Hodge


Biogenic Amine Tetrahydrocannabinol 


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  1. [1]
    Mayor's Committee on Marihuana,The marihuana Problem in the City of New York. Sociological, Medical. Psychological, and Pharmacological Studies (Jacques Cattell Press, Lancaster, Pennsylvania 1944).Google Scholar
  2. [2]
    H. Isbell, C. W. Gorodetzsky, D. Jasinski, U. Claussen, F. v. Spulak andF. Korte,Effects of (−) β 9 -Trans-Tetrahydrocannabinol in Man, Psychopharmacologica11, 184–188 (1967).CrossRefGoogle Scholar
  3. [3]
    R. Adams, M. Harfenst andS. Loewe,New Analogs of Tetrahydrocannabinol XIX, J. Am. Chem. Soc.71, 1624–1628 (1949).CrossRefGoogle Scholar
  4. [4]
    Y. Gaoni andJ. Mechoulam,Hashish III. The Isolation, Structure Partial Synthesis of an Active Constituent of Hashish, J. Am. Chem. Soc.86, 1646 to 1647 (1964).Google Scholar
  5. [5]
    F. Korte, M. Haag andU. Claussen,Tetrahydrocannabinolcarboxylic Acid, a Component of Hashish, Angew. Chem. (Intern. Ed.)4, 872 (1965).CrossRefGoogle Scholar
  6. [6]
    E. C. Taylor, K. Lenard andY. Shvo,Active Constituents of Hashish. Synthesis of dl-β 6 -3, 4, Trans-Tetrahydrocannabinol, J. Am. Chem. Soc.88, 367–369 (1966).CrossRefGoogle Scholar
  7. [7]
    D. E. Fahrenholtz, M. Lurie andR. W. Kierstead The Total Synthesis of dl-β 9 -Tetrahydrocannabinol and of dl-β- 8 -Tetrahydrocannabinol Racemates of Active Constituents of Marihuana, J. Am. Chem. Soc.88, 2079–2080 (1966).CrossRefGoogle Scholar
  8. [8]
    Y. Gaoni andJ. Mechoulam,Hashish IX. Concerning the Isomerization of β 1 -to β 1 { 6 }-Tetrahydrocannabinol,88, 5673–5675 (1966).Google Scholar
  9. [9]
    S. Loewe,Studies on the Pharmacology and Acute Toxicity of Compounds with Marihuana Activity, J. Pharmac. exp. Ther.88, 1954–1961 (1946).Google Scholar
  10. [10]
    T. P. Davis andH. H. Ramsey,Antiepileptic Action of Marihuana Active Substances, Fedn Proc.8, 284–285 (1949).Google Scholar
  11. [11]
    S. Loewe andL. S. Goodman,Anticonvulsant Action of Marihuana-Like Substances, Fedn Proc.6, 352 (1947).Google Scholar
  12. [12]
    S. Loewe,Cannabiswirkstoffe und Pharmakologie der Kannabinole, Arch. exp. Path. Pharmak.211, 175–193 (1950).Google Scholar
  13. [13]
    R. Dagirmanjian andE. S. Boyd,Some Pharmacological Effects of Two Tetrahydrocannabinols, J. Pharmac. exp. Ther.135, 25–33 (1962).Google Scholar
  14. [14]
    C. A. M. Sampaio, A. J. Lapa andJ. R. Valle,Influence of Cannabis Tetrahydrocannabinol and Parahexylon the Linguomandibular Reflex of Dog, J. Pharm. Pharmac.19, 552–554 (1967).Google Scholar
  15. [15]
    S. Loewe,Synergism of Cannabis and Butyl-bromoallylbarbituric Acid, J. Am. Pharm. Ass. Sci. Ed.29, 162–163 (1940).Google Scholar
  16. [16]
    J. C. Garriott, L. J. King, R. B. Forney andF. W. Hughes,Effects of Some Tetrahydrocannabinols on Sleeping Time and Amphetamine Induced Hyperactivity in Mice, Life Sci.6, 2119–2128 (1967).CrossRefPubMedGoogle Scholar
  17. [17]
    E. S. Boyd, E. D. Hutchinson, L. C. Gardner andD. A. Meritt,Effects of Tetrahydrocannabinols and Other Drugs on Operant Behavior in Rats, Arch. Int. Pharmacodyn. Ther.144, 533–554 (1963).PubMedGoogle Scholar
  18. [18]
    E. S. Boyd andD. A. Meritt,Effects of Thiopental and a Tetrahydrocannabinol Derivative of Arousal and Recruiting in the Cat, J. Pharmac. exp. Ther.149, 138–145 (1965).Google Scholar
  19. [19]
    E. S. Boyd andD. A. Meritt,Effects of Barbiturates and a Tetrahydrocannabinol Derivative on Recovery Cycles of Medial Lemniscus, Thalamus and Reticular Formation in the Cat, J. Pharmac. exp. Ther.151, 376 to 384 (1966).Google Scholar
  20. [20]
    H. J. Bein,The Pharmacology of Rauwolfia, Pharmac. Rev.8, 435–483 (1956).Google Scholar
  21. [21]
    J. J. Lewis,Rauwolfia Alkaloids, J. Pharm. Pharmac.8, 465–494 (1956).Google Scholar
  22. [22]
    H. J. Bein,Zur Pharmakologie der Reserpine eines neuen Alkaloids aus Rauwolfia serpentina Benth., Experientia9, 107–110 (1953).Google Scholar
  23. [23]
    J. H. Trapold, A. J. Plummer andF. F. Yonkman,Cardiovascular and Respiratory Effects of Serpasil, a New Crystalline Alkaloid from Serpentina Benth. in the Dog, J. Pharmac. exp. Ther.110, 205–214 (1954).Google Scholar

Copyright information

© Birkhäuser Verlag 1969

Authors and Affiliations

  • Rose Dagirmanjian
    • 1
    • 2
  • Harold C. Hodge
    • 1
    • 2
  1. 1.Departments of PharmacologyOhio State University College of MedicineColumbus
  2. 2.School of Medicine and DentistryUniversity of RochesterRochester

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