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Archives of Toxicology

, Volume 64, Issue 6, pp 466–469 | Cite as

Haemopoietic stem cells in mice chronically exposed to styrene vapour

  • Hans Joachim Seidel
  • Jochen Herkommer
  • Dietmar Seitz
  • Lothar Weber
  • Edda Barthel
Article

Abstract

Female C57BL/6× DBA/2 hybrid mice were exposed to two concentrations of styrene in inhalation chambers for 6 h/day, 5 days per week. The concentrations were 220 ppm for a period of up to 8 weeks and 440 ppm for 2 days, followed by 330 ppm for up to 8 weeks due to early deaths after 440 ppm. Parallel groups were also treated with 5% ethanol in the drinking water during the days of styrene exposure. In the peripheral blood only a lymphocytopenia was found. The numbers of pluripotent haemopoietic stem cells, CFU-S, were unaffected, as were granuloid committed stem cells, CFU-C. Early and late erythroid stem cell numbers, BFU-E and CFU-E, showed high variability. At 220 ppm about half of the animals had CFU-E numbers below 80% of controls, at 440/330 ppm about two-thirds of the animals had BFU-E and CFU-E numbers below this level. An additional effect of ethanol was not found.

Key words

Styrene Mice Inhalation Haemopoietic stem cells 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Hans Joachim Seidel
    • 1
  • Jochen Herkommer
    • 1
  • Dietmar Seitz
    • 1
  • Lothar Weber
    • 1
  • Edda Barthel
    • 1
  1. 1.Institute for Occupational and Social MedicineUniversity of UlmUlmFederal Republic of Germany

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