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Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice

Experientia volume 36, pages 1211–1212 (1980)Cite this article

Summary

Mice were painted with mechlorethamine (HN2), carmustine (BCNU) and lomustine (CCNU) for up to 33 weeks. HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series. BCNU was a weak carcinogen. CCNU produced no tumors in 1 series.

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Author information

Affiliations

  1. Departments of Dermatology and Pathology, University of California Medical Center, 94143, San Francisco, California, USA

    H. S. Zackheim & E. A. Smuckler

Authors
  1. H. S. Zackheim
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  2. E. A. Smuckler
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Additional information

Supported in part by PHS grant CA-14825 from the National Cancer Institute.

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Zackheim, H.S., Smuckler, E.A. Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice. Experientia 36, 1211–1212 (1980). https://doi.org/10.1007/BF01976135

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  • DOI: https://doi.org/10.1007/BF01976135

Keywords

  • Carcinoma
  • Cell Carcinoma
  • Squamous Cell Carcinoma
  • Squamous Cell
  • BCNU