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Unusually strong lipophilicity of ‘fat’ or ‘super’ amino-acids, including a new reference value for glycine

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Summary

Lipophilic, steric, electronic, and enzyme resistance characteristics of carboranylalanine, adamantylalanine, neopentylglycine and tert-butylglycine are described. The first 2 amino-acids display lipophilicities 2 orders of magnitude higher than tryptophan.

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Authors and Affiliations

  1. Department of Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH), CH-8093, Zürich, Switzerland

    J. L. Fauchère, Kim Quang Do, P. Y. C. Jow & C. Hansch

  2. Department of Chemistry, Pomona College, 91711, Claremont, CA, USA

    J. L. Fauchère, Kim Quang Do, P. Y. C. Jow & C. Hansch

Authors
  1. J. L. Fauchère
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  2. Kim Quang Do
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  3. P. Y. C. Jow
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  4. C. Hansch
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Additional information

This work was supported by research grants to Prof. R. Schwyzer from the Swiss National Science Foundation.

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Fauchère, J.L., Do, K.Q., Jow, P.Y.C. et al. Unusually strong lipophilicity of ‘fat’ or ‘super’ amino-acids, including a new reference value for glycine. Experientia 36, 1203–1204 (1980). https://doi.org/10.1007/BF01976129

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