Summary
The intestinal vasodilation evoked by mechanical mucosal stimulation or by transmural electrical field stimulation was abolished by close i.a. injection of Apamin, a polypeptide originally isolated from bee venom. Apamin also blocked the vasodilatation induced by close i.a. infusion of vasoactive intestinal polypeptide (VIP). It is suggested that Apamin is a VIP receptor antagonist.
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References
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This research was sponsored by grants from the Swedish Medical Research Council (14X-2855), from the Swedish Society for Medical Sciences, from Magnus Bergvalls Stiftelse and from the Medical Faculty, University of Göteborg.
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Sjöqvist, A., Delbro, D., Jodal, M. et al. The effect of Apamin® on nonadrenergic, noncholinergic nervous vasodilatations in the cat small intestine. Experientia 36, 1202 (1980). https://doi.org/10.1007/BF01976128
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DOI: https://doi.org/10.1007/BF01976128