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Desensitization of the muscarinic receptor of bullfrog atrial muscle

Experientia volume 36, pages 1200–1201 (1980)Cite this article

Summary

The muscarinic ACh receptors, which hyperpolarize the resting membrane and also depress the action potential of bullfrog atrial muscle, show desensitization to the action of ACh. This suggests that the molecular mechanism of these muscarinic ACh receptor-ionic channel (voltage-dependent) complexes is comparable to that of the nicotinic ACh receptor-ionic channel (voltage-independent) complex of the end-plate.

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Affiliations

  1. Department of Physiology, Kurume University School of Medicine, 830, Kurume, (Japan)

    T. Tokimasa, H. Hasuo & K. Koketsu

Authors
  1. T. Tokimasa
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  2. H. Hasuo
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  3. K. Koketsu
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Additional information

Acknowledgment. This work was supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

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Tokimasa, T., Hasuo, H. & Koketsu, K. Desensitization of the muscarinic receptor of bullfrog atrial muscle. Experientia 36, 1200–1201 (1980). https://doi.org/10.1007/BF01976127

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  • DOI: https://doi.org/10.1007/BF01976127

Keywords

  • Molecular Mechanism
  • Muscarinic Receptor
  • Atrial Muscle