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Desensitization of the muscarinic receptor of bullfrog atrial muscle

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Summary

The muscarinic ACh receptors, which hyperpolarize the resting membrane and also depress the action potential of bullfrog atrial muscle, show desensitization to the action of ACh. This suggests that the molecular mechanism of these muscarinic ACh receptor-ionic channel (voltage-dependent) complexes is comparable to that of the nicotinic ACh receptor-ionic channel (voltage-independent) complex of the end-plate.

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References

  1. S. Thesleff, Acta physiol. scand.34, 218 (1955).

    Article  CAS  Google Scholar 

  2. B. Katz and S. Thesleff, J. Physiol. (Lond.)138, 63 (1957).

    Article  CAS  PubMed  Google Scholar 

  3. D. Garnier, J. Nargeot, C. Ojeda and O. Rougier, J. Physiol. (Lond.)274, 381, (1978).

    Article  CAS  PubMed  Google Scholar 

  4. H.G. Glitsch and L. Pott, J. Physiol. (Lond.)279, 655 (1978).

    Article  CAS  PubMed  Google Scholar 

  5. T. Akasu, Y. Ohta and K. Koketsu, Experientia34, 488 (1978).

    Article  CAS  PubMed  Google Scholar 

  6. G.W. Beeler, Jr, and H. Reuter, J. Physiol. (Lond.)207, 165 (1970).

    Article  PubMed  Google Scholar 

  7. D. Noble, in: The Initiation of the Heartbeat. Oxford University Press, 1975.

  8. Y. Ikemoto and M. Goto, Proc. Japan Acad.51, 501 (1975).

    Article  CAS  Google Scholar 

  9. W. Giles and S.J. Noble, J. Physiol. (Lond.)261, 103 (1976).

    Article  CAS  PubMed  Google Scholar 

  10. P.D. Bregestovksi, E.A. Bukharaeva and V.I. Iljin, J. Physiol. (Lond.)297, 581 (1979).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Kurume University School of Medicine, 830, Kurume, Japan

    T. Tokimasa, H. Hasuo & K. Koketsu

Authors
  1. T. Tokimasa
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  2. H. Hasuo
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  3. K. Koketsu
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Additional information

Acknowledgment. This work was supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

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Tokimasa, T., Hasuo, H. & Koketsu, K. Desensitization of the muscarinic receptor of bullfrog atrial muscle. Experientia 36, 1200–1201 (1980). https://doi.org/10.1007/BF01976127

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