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Occurrence of inhibitory histamine H2-receptors in isolated pulmonary blood vessels of dogs and rats

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Summary

Isolated, helically cut strips of pulmonary arteries and veins of dogs, and pulmonary arteries of rats, precontracted with norepinephrine or 5-HT exhibited potent concentration-dependent relaxations to impromidine and dimaprit (histamine H2-agonists). The occurrence of inhibitory histamine H2-receptors in the pulmonary vasculature could play a modulatory role in hypoxic pulmonary vasoconstriction.

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Authors and Affiliations

  1. Department of Physiology, State University of New York, Downstate Medical Center, 11203, Brooklyn, New York, USA

    N. Chand & B. M. Altura

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  1. N. Chand
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  2. B. M. Altura
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Additional information

Supported by research grants NHLBI-18002, NHLBI-18015 and DA-02339 from the USPHS. We are grateful to Dr D.D.A. Owen of Smith, Kline & French Ltd, England for the generous supply of dimaprit and impromidine. Requests for reprints should be addressed to B.M. Altura.

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Chand, N., Altura, B.M. Occurrence of inhibitory histamine H2-receptors in isolated pulmonary blood vessels of dogs and rats. Experientia 36, 1186–1187 (1980). https://doi.org/10.1007/BF01976118

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