, Volume 36, Issue 10, pp 1153–1154 | Cite as

Inhibition of thiamine transport in baker's yeast by methylene blue

  • A. Iwashima
  • H. Nishimura
  • H. Nishino


Methylene blue was found to inhibit thiamine transport competitively (Ki=0.63 μM) in baker's yeast. The dye was also effective in abolishing the growth inhibition ofSaccharomyces cerevisiae by pyrithiamine which is known to be taken up by a common transport system for thiamine in yeast cells. A possible mechanism for the inhibition by methylene blue of the thiamine transport system in baker's yeast is discussed.


Methylene Growth Inhibition Methylene Blue Yeast Cell Transport System 
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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • A. Iwashima
    • 1
  • H. Nishimura
    • 1
  • H. Nishino
    • 1
  1. 1.Department of BiochemistryKyoto Prefectural University of MedicineKyoto(Japan)

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