Experientia

, Volume 36, Issue 10, pp 1143–1144 | Cite as

Characteristic changes of cerebellar proteins associated with cerebellar hypoplasia in jaundiced Gunn rats and the prevention of these by phototherapy

  • S. Kashiwamata
  • S. Aono
  • R. K. Semba
Specialia

Summary

In the cerebellar particulate fractions from Gunn rat homozygotes 3 protein bands with apparent mol.wts of 250,000, 50,000 and 33,000 in SDS-polyacrylamide gel disc electrophoresis underwent major changes, and phototherapy of the newborns could effectively prevent the changes.

Keywords

Electrophoresis Protein Band Major Change Particulate Fraction Characteristic Change 

References

  1. 2.
    C.K. Gunn, J. Hered.29, 137 (1938).Google Scholar
  2. 3.
    H.S. Schutta and L. Johnson, J. Neuropath. exp. Neurol.26, 377 (1967).PubMedGoogle Scholar
  3. 4.
    T.R.C. Sisson, S. Goldberg and B. Slaven, Pediat. Res.8, 647 (1974).PubMedGoogle Scholar
  4. 5.
    Y. Sawasaki, N. Yamada and H. Nakajima, J. Neurochem.27, 577 (1976).PubMedGoogle Scholar
  5. 6.
    H. Sato, R.K. Semba and S. Kashiwamata, Biol. Neonate32, 158 (1977).PubMedGoogle Scholar
  6. 7.
    P.E. Burba and R. Zand, Biochem. biophys. Res. Commun.58, 1142 (1974).CrossRefPubMedGoogle Scholar
  7. 8.
    A. Greenfield and A.P.N. Majumdar, J. neurol. Sci.22, 83 (1974).CrossRefPubMedGoogle Scholar
  8. 9.
    G.F.L. Ames, J. biol. Chem.249, 634 (1974).PubMedGoogle Scholar
  9. 10.
    O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall, J. biol. Chem.193, 265 (1951).PubMedGoogle Scholar
  10. 11.
    G. Fairbanks, T.L. Steck and D.F.H. Wallach, Biochemistry10, 2606 (1971).PubMedGoogle Scholar
  11. 12.
    J. Mallett, M. Huchet, R. Pougeois and J.P. Changeux, Brain Res.103, 291 (1976).CrossRefPubMedGoogle Scholar
  12. 13.
    A. Hirano and H.M. Dembitzer, J. Neuropath. exp. Neurol.34, 1 (1975).PubMedGoogle Scholar
  13. 14.
    S.C. Landis, J. Cell Biol.57, 782 (1973).CrossRefPubMedGoogle Scholar
  14. 15.
    Y. Tamaki and Y. Yamasaki, Physiol. Behav.17, 615 (1976).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • S. Kashiwamata
    • 1
  • S. Aono
    • 1
  • R. K. Semba
    • 1
  1. 1.Department of Perinatology, Institute for Developmental ResearchAichi Prefecture ColonyKasugai, Aichi(Japan)

Personalised recommendations