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Regression of genetically determined polycystic kidney disease in murine organ culture

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Summary

Cystic kidneys from the mutant CPK strain of C57BL/6J mice were cultured in serum-free organ culture. During 120 h of incubation in chemically-defined medium, CPK cystic tubular changes underwent complete regression. Environmental factors regulate the expression of genetically determined polycystic kidney disease in this model.

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Authors and Affiliations

  1. Division of Nephrology, Children's Hospital of Pittsburgh, 125 DeSoto Street, 15213, Pittsburgh, Pennsylvania, USA

    E. D. Avner, W. E. Sweeney Jr, N. P. Piesco & D. Ellis

Authors
  1. E. D. Avner
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  2. W. E. Sweeney Jr
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  3. N. P. Piesco
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  4. D. Ellis
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Avner, E.D., Sweeney, W.E., Piesco, N.P. et al. Regression of genetically determined polycystic kidney disease in murine organ culture. Experientia 42, 77–80 (1986). https://doi.org/10.1007/BF01975904

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  • DOI: https://doi.org/10.1007/BF01975904

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