Skip to main content
SpringerLink
Log in

Ethanol influence on insulin secretion from isolated rat islets

  • Short Communications
  • Endocrinology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

This study was done to delineate the role of α- and β-adrenergic receptors and cyclic AMP in the mechanism of ethanol effects on insulin release from isolated islets. Rats were given an α-adrenergic blocker, phentolamine, or a β-adrenergic blocker, propranolol. In addition, ethanol 1 g/kg was given intragastrically 1 h prior to sacrifice. Glucose mediated insulin release from isolated islets was enhanced by phentolamine and decreased by propranolol. Ethanol treatment inhibited glucose-induced insulin release from isolated islets of control rats as well as those given phentolamine and/or propranolol. Insulin release from isolated islets in response to dibutyryl-cyclic AMP was attenuated by ethanol. Theophylline enhanced glucose mediated insulin release from control islets but ethanol treatment produced a significant inhibition of insulin response. The data suggest that the site of action of the deleterious effects of ethanol on insulin release from isolated islets in rat does not involve adrenergic system and cyclic AMP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Ritchie, J. M., in: The Pharmacological Basis of Therapeutics p. 376. Eds Goodman, A. G., Goodman, L. S. and Gilman, A., MacMillan Publishing Co., Inc., New York 1970.

    Google Scholar 

  2. Sloan, I., Sawh, P., and Bihler, L., Molec. cell. Endocr.10 (1978) 3.

    Article  CAS  PubMed  Google Scholar 

  3. Unger, R. H., Dobbs, R. E., and Orci, L., A. Rev. Physiol.40 (1978) 307.

    Article  CAS  Google Scholar 

  4. Shah, J. H., Wongsurawat, N., and Aran, P. P., Diabetes26 (1977) 271.

    Article  CAS  PubMed  Google Scholar 

  5. Singh, S. P., and Patel, D. G., Metabolism25 (1976) 239.

    Article  CAS  PubMed  Google Scholar 

  6. Singh, S. P., Patel, D. G., and Snyder, A. K., Acta endocr.93 (1980) 61.

    CAS  PubMed  Google Scholar 

  7. Malaisse, W. J., Malaisse-Lagae, F., Walker, M. O., and Lacy, P. E., Diabetes20 (1971) 257.

    Article  CAS  PubMed  Google Scholar 

  8. Cohen, L. B., Sellers, E. M., Sellers, E. A., and Flattery, D. W., J. Pharmac. exp. Ther.212 (1980) 425.

    CAS  Google Scholar 

  9. Kuo, W. N., Modgins, D. S., and Kuo, J. F., J. biol. Chem.248 (1973) 2705.

    Article  CAS  PubMed  Google Scholar 

  10. Luyckx, M. D., and Lefebvre, P. J., Diabetes23 (1974) 81.

    Article  CAS  PubMed  Google Scholar 

  11. Patel, D. G., and Singh, S. P., Metabolism28 (1979) 85.

    Article  CAS  PubMed  Google Scholar 

  12. Blanks, M. C., and Gerritsen, G. C., Proc. Soc. exp. Biol. Med.146 (1974) 448.

    Article  CAS  PubMed  Google Scholar 

  13. Bonnichsen, R., and Theorell, H., Scand. J. clin Lab. Invest.3 (1951) 58.

    Article  CAS  PubMed  Google Scholar 

  14. Wollheim, C. G., and Sharp, G. W. G., Physiol. Rev.61 (1981) 914.

    Article  CAS  PubMed  Google Scholar 

  15. Malaisse, W. J., Brisson, B., and Malaisse-Lagae, F., J. Lab. clin. Med.76 (1970) 895.

    CAS  PubMed  Google Scholar 

  16. Coore, H. G., and Randle, P. J., Biochem. J.93 (1964) 66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Malaisse, W., Malaisse-Lagae, F., Wright, P. H., and Ashmore, J., Endocrinology80 (1967) 975.

    Article  CAS  PubMed  Google Scholar 

  18. Loubatieres, A., Mariani, M. A., and Chapal, J., Diabetologia6 (1970) 533.

    Article  CAS  PubMed  Google Scholar 

  19. Fain, J. N., Metabolism33 (1984) 672.

    Article  CAS  PubMed  Google Scholar 

  20. Malaisse, W. J., Sener, A., and Malaisse-Lagae, F., Molec. cell. Biochem.37 (1981) 157.

    Article  CAS  PubMed  Google Scholar 

  21. Colwell, A. R., Feinzimer, M., Cooper, D., and Zuckerman, L., Diagetes22 (1973) 854.

    CAS  Google Scholar 

  22. Hawkins, R. D., and Kalant, H., Pharmac. Rev.24 (1972) 67.

    CAS  Google Scholar 

Download references

Author information

Author notes

  1. D. G. Patel

    Present address: Department of Pharmacology, Meharry Medical College, 1005-18th Avenue North, 37208, Nashville, Tennessee, USA

Authors and Affiliations

  1. Medical Research Service, Veterans Administration Medical Center, 60064, North Chicago, Illinois, USA

    S. P. Singh, D. G. Patel, A. K. Snyder & G. L. Pullen

  2. Department of Medicine, Chicago Medical School, 60064, North Chicago, Illinois, USA

    S. P. Singh, D. G. Patel, A. K. Snyder & G. L. Pullen

Authors
  1. S. P. Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. G. Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. K. Snyder
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. L. Pullen
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the U.S. Veterans Administration

Rights and permissions

Reprints and permissions

About this article

Cite this article

Singh, S.P., Patel, D.G., Snyder, A.K. et al. Ethanol influence on insulin secretion from isolated rat islets. Experientia 42, 58–60 (1986). https://doi.org/10.1007/BF01975895

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01975895

Key words

Search

Navigation