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Suppression by the cyclohexanetrione Ro 31-0521 of retinoic acid-induced teratogenicity

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  • Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology
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Summary

The cyclohexanetrione Ro 31-0521, which stimulates prostaglandin synthesis, inhibited retinoic acid-induced cartilage degradation in vitro and suppressed the congenital forelimb malformations in rats treated with retinoic acid on day 13 of gestation in a dose-dependent manner.

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Authors and Affiliations

  1. Biological Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. Ltd, CH-4002, Basle, Switzerland

    A. Kistler

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  1. A. Kistler
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Additional information

I thank Dr J. Burckhardt for critical reading of the manuscript, Dr E. Lüdin for statistics and Miss B. Schröter and Mrs B. Galli for technical assistance.

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Kistler, A. Suppression by the cyclohexanetrione Ro 31-0521 of retinoic acid-induced teratogenicity. Experientia 42, 50–52 (1986). https://doi.org/10.1007/BF01975891

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  • DOI: https://doi.org/10.1007/BF01975891

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