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Experientia

, Volume 42, Issue 1, pp 37–39 | Cite as

Myelin changes in the rats CNS following intraventricular injection of serum

  • G. Konat
  • N. H. Diemer
  • H. Offner
Short Communications Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology

Summary

Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

Key words

Serum intrathecal injection CNS dissociated myelin demyelination multiple sclerosis 

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Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • G. Konat
    • 2
  • N. H. Diemer
    • 1
  • H. Offner
    • 1
  1. 1.Institute of Neuropathology and Institute of Medical PhysiologyUniversity of CopenhagenCopenhagen(Denmark)
  2. 2.Department of NeurologyMedical University of South CarolinaCharlestonUSA

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