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Failure of coffee to inhibit the pharmacodynamic activity of morphine in vivo

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  • Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology
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Summary

High doses of caffeine-containing as well as decaffeinated instant coffee neither inhibited morphine-induced analgesia in mice nor the morphine-induced fall of blood pressure, heart rate and respiratory rate in rats. On the contrary, caffeine-containing coffee even enhanced the analgesic effects of morphine in mice. Coffee thus does not exhibit opiate-antagonizing activity in the whole organism in vivo. The very weak morphine-antagonistic efficacy of coffee powder in the myenteric plexus-longitudinal muscle preparation from the guinea pig ileum is of no practical importance.

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Authors and Affiliations

  1. Institut für Toxikologie und Institut für Pharmakologie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-2400, Lübeck, Federal Republic of Germany

    O. Strubelt, M. Kaschube & G. Zetler

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  1. O. Strubelt
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  2. M. Kaschube
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  3. G. Zetler
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Strubelt, O., Kaschube, M. & Zetler, G. Failure of coffee to inhibit the pharmacodynamic activity of morphine in vivo. Experientia 42, 35–37 (1986). https://doi.org/10.1007/BF01975882

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  • DOI: https://doi.org/10.1007/BF01975882

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