Summary
Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery.
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Liu, T., Cavallini, M., Halberg, F. et al. More on the need for circadian, circaseptan and circannual optimization of cyclosporine therapy. Experientia 42, 20–22 (1986). https://doi.org/10.1007/BF01975877
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DOI: https://doi.org/10.1007/BF01975877