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Concentration of azithromycin in human prostatic tissue

  • Pharmacokinetics
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Prostatic tissue was obtained from 36 patients at two study locations and assayed for azithromycin by HPLC or bioassay. The mean concentration of azithromycin in human prostatic tissue (2.54 µg/ml) 14 h after 500 mg oral dosing (two 250 mg doses 12 h apart) was much greater than plasma concentrations (≤ 0.1 µg/ml). Azithromycin was slowly eliminated from prostatic tissue (half-life 60 h) and a mean concentration of 0.62 µg/ml remained 137 h after dosing.

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Authors and Affiliations

  1. Central, Research Division, Pfizer Inc., Eastern Point Road, 06340, Groton, Connecticut, USA

    G. Foulds, R. Shepard & R. Johnson

  2. Urology Section, Veterans Administration Hospital, 53705, Madison, Wisconsin, USA

    P. Madsen

  3. Department of Urology, College of Medicine, University of Tennessee, 38163, Memphis, Tennessee, USA

    C. Cox

Authors
  1. G. Foulds
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  2. P. Madsen
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  3. C. Cox
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  4. R. Shepard
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  5. R. Johnson
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Foulds, G., Madsen, P., Cox, C. et al. Concentration of azithromycin in human prostatic tissue. Eur. J. Clin. Microbiol. Infect. Dis. 10, 868–871 (1991). https://doi.org/10.1007/BF01975845

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  • DOI: https://doi.org/10.1007/BF01975845

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