Abstract
The in vitro activity of GR69153 was compared to that of ceftazidime, ceftriaxone, imipenem and gentamicin against a total of 702 recent clinical isolates. MICs were determined by a standard agar dilution procedure and two inocula (104 and 108 cfu) were used throughout. GR69153 inhibited 90 % of isolates ofEscherichia coli, Klebsiella pneumonia andProteus mirabilis at ≤0.25 mg/l and 90 % of isolates ofPseudomonas aeruginosa at ≤1 mg/l.Citrobacter freundii (MIC90 16 mg/l),Morganella morganii (MIC90 128 mg/l) andEnterobacter spp. (MIC90>128 mg/l) were considerably more resistant to GR69153. GR69153 was four-fold more active than ceftazidime against methicillin-sensitiveStaphylococcus aureus but was inactive against methicillin-resistantStaphylococcus aureus, Enterococcus faecalis andBacteroides fragilis group.
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Clarke, A.M., Zemcov, S.J.V. In vitro activity of the novel cephalosporin GR69153. Eur. J. Clin. Microbiol. Infect. Dis. 10, 683–687 (1991). https://doi.org/10.1007/BF01975826
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DOI: https://doi.org/10.1007/BF01975826