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Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice

  • Inflammation
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Abstract

A study was conducted to evaluate the effects of a new, highly selective plasma kallikrein inhibitor, PKSI-527, on collagen-induced arthritis (CIA) in mice. PKSI-527 or indomethacin was administered daily intraperitoneally from day 20 postimmunization. Clinical evaluation was performed, and two of the components of the kallikrein-kinin system, high-molecular-weight (HMW) kininogen and plasma prekallikrein, were assyed. PKSI-527, as well as indomethacin, reduced the severity of arthritis significantly. PKSI-527, but not indomethacin, restored consumed components of the kallikrein-kinin system. These results suggest that PKSI-527 suppresses CIA by modifying the kallikrein-kinin system and PKSI-527 as a synthetic plasma kallikrein inhibitor would be a valuable tool to study the mechanism of inflammation of arthritic diseases.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, 54 Shogoin-kawahara-cho, Sakyo-ku, 606, Kyoto, Japan

    Y. Fujimori, K. Shimizu & T. Yamamuro

  2. Research Center for Biomedical Engineering, Kyoto University, 53 Shogoin-kawahara-cho, Sakyo-ku, 606, Kyoto, Japan

    T. Nakamura

  3. Kobe Research Projects on Thrombosis and Haemostasis, Asahigaoka, Tarumi-ku, 655, Kobe, Japan

    K. Wanaka & S. Okamoto

  4. Life Science Research Laboratory, Showa Denko Co., Ltd., Tamagawa, Ohta-ku, 146, Tokyo, Japan

    Y. Katsuura

Authors
  1. Y. Fujimori
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  2. T. Nakamura
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  3. K. Shimizu
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  4. T. Yamamuro
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  5. K. Wanaka
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  6. S. Okamoto
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  7. Y. Katsuura
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Fujimori, Y., Nakamura, T., Shimizu, K. et al. Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice. Agents and Actions 39, 42–48 (1993). https://doi.org/10.1007/BF01975713

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  • DOI: https://doi.org/10.1007/BF01975713

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