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Effects of cilofungin (LY121019) on carbohydrate and sterol composition ofCandida albicans

  • M. Pfaller
  • J. Riley
  • T. Koerner
New Antimicrobial Agents

Abstract

Cilofungin (LY121019) is a novel analogue of echinocandin B with potent activity againstCandida albicans. The effects of cilofungin on the sterol and cell wall carbohydrate composition ofCandida albicans were investigated. Exposure ofCandida albicans to cilofungin resulted in a 55–60% decrease in ergosterol and a 4–13% decrease in lanosterol content relative to controls. Carbohydrate analysis revealed a 72–79% decrease in glucan content and no significant decrease in mannan or chitin content relative to controls. These studies suggest that cilofungin specifically inhibits glucan synthesis inCandida albicans and thus may be less toxic to mammalian cells. The effects of cilofungin on sterol composition may be non-specific and will require additional investigation.

Keywords

Carbohydrate Chitin Glucan Ergosterol Additional Investigation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Viewey & Sohn Verlagsgesellschaft mbH 1989

Authors and Affiliations

  • M. Pfaller
    • 1
    • 2
  • J. Riley
    • 1
  • T. Koerner
    • 2
  1. 1.Veterans Administration Medical CenterUniversity of Iowa College of MedicineIowa CityUSA
  2. 2.Department of Pathology, 273 MRCUniversity of Iowa College of MedicineIowa CityUSA

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