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Comparative in vitro antibacterial activity of the new carbapenem meropenem (SM-7338)

  • New Antimicrobial Agents
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Abstract

The in vitro antimicrobial activity of the new carbapenem meropenem (SM-7338) was determined by an agar dilution method in comparison with imipenem, ticarcillin/calvulanic acid, ceftazidime and the fourth-generation cephalosporin cefepime (BMY 28142). Meropenem showed superior activity againstEnterobacteriaceae (MIC90≤0.06 mg/l) and against non-fermentative gram-negative rods, with the exception ofXanthomonas maltophilia. Meropenem had excellent activity against beta-lactamase-producingHaemophilus influenzae andNeisseria gonorrhoeae, and against theBacteroides fragilis group. Imipenem was slightly more active then meropenem against gram-positive cocci especiallyEnterococcus faecalis.

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Authors and Affiliations

  1. Department of Clinical Microbiology and Laboratory of Infectious Diseases, University Hospital, PO Box 85500, 3508 GA, Utrecht, The Netherlands

    M. R. Visser, I. M. Hoepelman, H. Beumer, M. Rozenberg-Arska & J. Verhoef

Authors
  1. M. R. Visser
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  2. I. M. Hoepelman
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  3. H. Beumer
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  4. M. Rozenberg-Arska
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  5. J. Verhoef
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Visser, M.R., Hoepelman, I.M., Beumer, H. et al. Comparative in vitro antibacterial activity of the new carbapenem meropenem (SM-7338). Eur. J. Clin. Microbiol. Infect. Dis. 8, 1061–1064 (1989). https://doi.org/10.1007/BF01975170

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  • DOI: https://doi.org/10.1007/BF01975170

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