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Antibacterial and plasmid curing activity of lomefloxacin in vitro

  • New Antimicrobial Agents
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Abstract

The in vitro activity of lomefloxacin in comparison to other recently developed quinolones was evaluated by determination of MICs for 89 test strains. Organisms tested included clinical isolates of gram-positive and gram-negative bacteria susceptible or resistant to quinolones, resistant mutants ofEnterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus aureus andEnterococcus faecalis obtained in vitro, and the wild type strainEscherichia coli K12 with its mutantsna1A, nalB, nalC andnalB. The activity of lomefloxacin was similar to that of pefloxacin against gram-positive cocci and similar to that of norfloxacin against gram-negative bacteria. There was cross-resistance to all quinolones tested in pefloxacin resistant clinical isolates and in laboratory mutants. The activity of lomefloxacin was decreased against theEscherichia coli K12 mutantsnalA andnalD but notnalB, whereas thenalC mutant showed increased susceptibility. Susceptible and mutant strains (n=115) were used to establish the least-squares lines of regression with 5-µg and 10-µg lomefloxacin disks. Tests of the in vitro plasmid curing activity of lomefloxacin compared to other agents showed no statistically significant plasmid loss after treatment with lomefloxacin.

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Authors and Affiliations

  1. Unité des Agents Antibactériens, CNRS UA 271, Centre National de Référence des Antibiotiques, Institut Pasteur, 28 rue du Dr. Roux, 75724, Paris Cédex 15, France

    E. Derlot, C. Poyart-Salmeron & P. Courvalin

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  1. E. Derlot
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  2. C. Poyart-Salmeron
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  3. P. Courvalin
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Derlot, E., Poyart-Salmeron, C. & Courvalin, P. Antibacterial and plasmid curing activity of lomefloxacin in vitro. Eur. J. Clin. Microbiol. Infect. Dis. 8, 1048–1052 (1989). https://doi.org/10.1007/BF01975168

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