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Single-dose ciprofloxacin in the treatment of uncomplicated urinary tract infection in women

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Abstract

In a randomised, double-blind trial two single-dose regimens of ciprofloxacin were evaluated for treatment of acute urinary tract infection (UTI) in women. Fifty-three women received 250mg and 46 750mg of ciprofloxacin. Seven days after treatment the eradication rate was 81.1% and 82.6% in the low and high dose groups respectively; the clinical cure rate at 28 days was 64.1% and 73.9% respectively. In women with recurrent UTI a significantly better response was found with the high dose regimen (92% versus 68%; p<0.001). It is concluded that a single 250mg dose of ciprofloxacin is effective for treatment in most women with acute UTI, but in women with recurrent infection a 750mg dose is preferable.

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References

  1. Asscher, A. W. Diseases of the urinary system. Urinary tract infections. British Medical Journal 1977, i: 1332–1334.

    Google Scholar 

  2. Tolkoff-Rubin, N. E., Weber, D., Fang, L. S., Kelly, M., Wilkinson, R., Rubin, R. H. Single-dose therapy with trimethoprim-sulfamethoxazole for urinary tract infection in women. Reviews of Infectious Diseases 1982, 4: 444–450.

    PubMed  Google Scholar 

  3. Kunin, C. M. Duration of treatment of urinary tract infections. American Journal of Medicine 1981, 71: 849–854.

    Article  PubMed  Google Scholar 

  4. Raz, R., Genesin, J., Gonen, E., Shmilovitz, M., Hefter, H., Potasman, I. Single low-dose ofloxacin for the treatment of uncomplicated urinary tract infection in young women. Journal of Antimicrobial Chemotherapy 1988, 22: 945–949.

    PubMed  Google Scholar 

  5. Hooper, D. C., Wolfson, J. S. The fluoroquinolones: pharmacology, clinical uses, and toxicity in humans. Antimicrobial Agents and Chemotherapy 1985, 28: 716–721.

    PubMed  Google Scholar 

  6. Monk, J. P., Campoli-Richards, D. Ofloxacin, a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Journal of Antimicrobial Chemotherapy 1986, 3: 346–391.

    Google Scholar 

  7. Garlando, F., Rietiker, S., Tanker, M. G., Fleep, M., Meier, B., Luthy, R. Single-dose ciprofloxacin at 100mg versus 250mg for treatment of uncomplicated urinary tract infections in women. Antimicrobial Agents and Chemotherapy 1987, 31: 354–356.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Infectious Diseases Unit, Central Emek Hospital, 18101, Afula, Israel

    R. Raz

  2. Clinical Microbiology Laboratory, Central Emek Hospital, 18101, Afula, Israel

    Y. Kennes

  3. Zvulun Clinic, Kiriat Motzkin, Israel

    E. Rottensterich

  4. Hirsch Regional Microbiology Laboratory, Kupat Holim, Haifa, Israel

    H. Hefter

  5. Infectious Diseases Unit, Haifa City Medical Center, Haifa, Israel

    I. Potasman

Authors
  1. R. Raz
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  2. E. Rottensterich
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  3. H. Hefter
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  4. Y. Kennes
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  5. I. Potasman
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Raz, R., Rottensterich, E., Hefter, H. et al. Single-dose ciprofloxacin in the treatment of uncomplicated urinary tract infection in women. Eur. J. Clin. Microbiol. Infect. Dis. 8, 1040–1042 (1989). https://doi.org/10.1007/BF01975166

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  • DOI: https://doi.org/10.1007/BF01975166

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