, Volume 36, Issue 4, pp 383–384 | Cite as

Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits

  • P. T. Annamala
  • K. T. Augusti


Treatment of alloxan diabetic rabbits with glibenclamide, the most potent of the sulfonylureas, for a period of 2 months, significantly ameliorated the diabetic condition. It produced a decrease in serum and liver lipids, amino acids, serum urea, blood sugar and urine sugar; increase in body weight, serum and liver proteins, liver glycogen, glucose tolerance and serum and liver acid labile phosphates. The possible mechanism of action of this hypoglycemic agent is discussed.


Sulfonylurea Glibenclamide Diabetic Animal Alloxan Serum Urea 
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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • P. T. Annamala
    • 1
  • K. T. Augusti
    • 1
  1. 1.Department of BiochemistryUniversity of KeralaTrivandrumIndia

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