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Experientia

, Volume 36, Issue 4, pp 383–384 | Cite as

Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits

  • P. T. Annamala
  • K. T. Augusti
Article

Summary

Treatment of alloxan diabetic rabbits with glibenclamide, the most potent of the sulfonylureas, for a period of 2 months, significantly ameliorated the diabetic condition. It produced a decrease in serum and liver lipids, amino acids, serum urea, blood sugar and urine sugar; increase in body weight, serum and liver proteins, liver glycogen, glucose tolerance and serum and liver acid labile phosphates. The possible mechanism of action of this hypoglycemic agent is discussed.

Keywords

Sulfonylurea Glibenclamide Diabetic Animal Alloxan Serum Urea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • P. T. Annamala
    • 1
  • K. T. Augusti
    • 1
  1. 1.Department of BiochemistryUniversity of KeralaTrivandrumIndia

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