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Comparative in vitro activity of A-56268

  • New Antimicrobial Agents
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The comparative in vitro activity of A-56268 was studied using 1,006 clinical isolates including streptococci, enterococci, staphylocci,Neisseria gonorrhoeae, Haemophilus influenzae and anaerobes. A-56268 showed activity comparable to that of erythromycin and was more active than josamycin and roxithromycin against erythromycin-sensitive aerobic and facultatively anaerobic gram-positive cocci. A-56268 was the most active macrolide againstClostridium spp. andNeisseria gonorrhoeae. Josamycin was more active than either A-56268 or erythromycin against the anaerobic gram-positive cocci and theBacteroides fragilis group. Staphylococci moderately resistant or resistant to erythromycin (MIC 3.12–50 mg/l) remained susceptible to josamycin but not the other macrolides.

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Authors and Affiliations

  1. Department of Medical Microbiology, The London Hospital Medical College, Turner Street, El 2AD, London, UK

    A. M. Sefton, J. P. Maskell & J. D. Williams

  2. Institute of Clinical Pharmacology, Beijing Medical University, Beijing, People's Republic of China

    F. J. Yong

  3. Solah Medical Centre, Kota Kinabalu, Malaysia

    Chi Shu-Jing

Authors
  1. A. M. Sefton
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  2. J. P. Maskell
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  3. F. J. Yong
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  4. Chi Shu-Jing
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  5. J. D. Williams
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Sefton, A.M., Maskell, J.P., Yong, F.J. et al. Comparative in vitro activity of A-56268. Eur. J. Clin. Microbiol. Infect. Dis. 7, 798–802 (1988). https://doi.org/10.1007/BF01975054

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  • DOI: https://doi.org/10.1007/BF01975054

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